Human Atopic Dermatitis Peripheral Blood Mononuclear Cells

Description

Human Atopic Dermatitis Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with atopic dermatitis (AD), a chronic inflammatory skin disorder. These cells primarily consist of lymphocytes (T cells, B cells, and NK cells) and monocytes, which are key components in the immune response. AD-PBMCs are functionally implicated in the dysregulated immune response characteristic of AD, particularly through Th2-skewed cytokine production (e.g., IL-4, IL-5, IL-13) and IgE-mediated hypersensitivity. They also exhibit abnormal T-cell activation and altered function of monocyte-derived dendritic cells, contributing to skin barrier impairment and chronic inflammation.

Application

• Human Atopic Dermatitis Peripheral Blood Mononuclear Cells can be used to explore the molecular mechanisms underlying Th2-biased immune responses, skin barrier dysfunction and chronic inflammation. They are also suitable for in vitro experiments, such as cell culture, cytokine detection (such as IL-4, IL-5, IL-13 and IL-31), and flow cytometry analysis of changes in immune cell subsets to reveal the immune dysregulation characteristics of AD.