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Human Atopic Dermatitis Peripheral Blood Mononuclear Cells

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Atopic dermatitis (eczema) is a disease that cause skin red and itchy. Clinical data may include: Medication (current and historical), Disease Severity, CU Incidence, SCORAD.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Atopic Dermatitis Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4337
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Atopic Dermatitis
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Atopic Dermatitis Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with atopic dermatitis (AD), a chronic inflammatory skin disorder. These cells primarily consist of lymphocytes (T cells, B cells, and NK cells) and monocytes, which are key components in the immune response. AD-PBMCs are functionally implicated in the dysregulated immune response characteristic of AD, particularly through Th2-skewed cytokine production (e.g., IL-4, IL-5, IL-13) and IgE-mediated hypersensitivity. They also exhibit abnormal T-cell activation and altered function of monocyte-derived dendritic cells, contributing to skin barrier impairment and chronic inflammation.

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Citation

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Application

  • Human Atopic Dermatitis Peripheral Blood Mononuclear Cells can be used to explore the molecular mechanisms underlying Th2-biased immune responses, skin barrier dysfunction and chronic inflammation. They are also suitable for in vitro experiments, such as cell culture, cytokine detection (such as IL-4, IL-5, IL-13 and IL-31), and flow cytometry analysis of changes in immune cell subsets to reveal the immune dysregulation characteristics of AD.

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