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Human B2M_HLA (A0201) K562 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human B2M_HLA (A0201) K562 Cell Line
Species

Human
Cat.No

ABC-X0369C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphoblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Bone Marrow
Disease

Chronic Myelogenous Leukemia
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

K562

Description

Human B2M_HLA (A0201) K562 Cell Line is a genetically engineered model derived from selected human chronic myeloid leukemia K562 parental cell line based on customers’ requirement. B2M_HLA (A0201) K562 overexpression cell line is generated by stable integration of exogenous human B2M and HLA-A0201 genes into K562 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
B2M and HLA-A0201 constitute the major histocompatibility complex class I (MHC-I), crucial for antigen presentation and immune surveillance. Restoring MHC-I surface expression in immune-deficient K562 cells enables T-cell recognition studies. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The B2M_HLA (A0201) K562 Overexpression Cell Line is widely used in immunotherapy research, especially for T-cell receptor (TCR) specificity, peptide-MHC interaction, and cytotoxicity assays in engineered T-cell screening platforms.

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