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Species | Human |
Cat.No | ABC-X0369C |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Transfected Stable Cell Lines |
Size/Quantity | 1 vial |
Cell Type | Lymphoblast |
Shipping Info | Dry Ice |
Growth Conditions | 37 °C, 5% CO2 |
Source Organ | Bone Marrow |
Disease | Chronic Myelogenous Leukemia |
Biosafety Level | 1 |
Storage | Liquid Nitrogen |
Product Type | Overexpression Stable Cell Lines |
Host Cell | K562 |
Human B2M_HLA (A0201) K562 Cell Line is a genetically engineered model derived from selected human chronic myeloid leukemia K562 parental cell line based on customers’ requirement. B2M_HLA (A0201) K562 overexpression cell line is generated by stable integration of exogenous human B2M and HLA-A0201 genes into K562 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
B2M and HLA-A0201 constitute the major histocompatibility complex class I (MHC-I), crucial for antigen presentation and immune surveillance. Restoring MHC-I surface expression in immune-deficient K562 cells enables T-cell recognition studies. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
For research use only