Human Bladder Epithelial Cells

Description

Human Bladder Epithelial Cells are primary cells isolated from normal human bladder tissue, consisting of basal (cuboidal), intermediate (polygonal), and umbrella cells. They form a barrier regulating urine flow and protecting the bladder from toxins and infection. These cells express key biomarkers including CK5+, CK7+, CK8+, CK18+, P63+, E-cadherin+, ZO-1+, and α-smooth muscle Actin–, confirming their epithelial identity and tight junction integrity. They are non-tumorigenic and non-metastatic, tested negative for mycoplasma, bacteria, yeast, fungi, and viral infections (including HIV-1, HIV-2, HTLV I, HTLV II), ensuring purity. Cryopreserved in liquid nitrogen, they are suitable for studies related to bladder function, urological diseases, and cancer research.

Application

• Human bladder epithelial cells offer a valuable in vitro model for studying and understanding the complex responses of the urinary bladder to various physiological and pathological conditions. By applying stretching forces, osmotic and hydrostatic pressures, toxins, and microbial invasion to these cells, researchers can gain insights into the molecular and cellular mechanisms underlying bladder function and dysfunction. These cells offer a unique opportunity to investigate the formation, progression, and resolution of diseases such as urinary tract infections and bladder cancer.