Human Bladder Epithelial Cells

Description

Human Bladder Epithelial Cells are derived from normal urinary bladder tissue and represent the non-transformed epithelial cell population lining the inner surface of the bladder (urothelium), and are frequently referenced in studies of bladder epithelium as representative normal epithelial cells, with detached counterparts sometimes examined clinically as normal epithelial cells in urine for comparison. These cells exhibit a cobblestone-like epithelial morphology and maintain tight junctions, a hallmark of urothelial barrier integrity. They express characteristic markers such as uroplakin, cytokeratin 7 (KRT7), and cytokeratin 20 (KRT20), as well as E-cadherin, indicating epithelial identity and polarization. Bladder epithelial cells are crucial for studying normal bladder physiology, host-pathogen interactions (e.g., uropathogenic E. coli), and urothelial responses to injury, inflammation, or carcinogens. Their gene expression profile supports research into barrier function, immune signaling, and epithelial differentiation.