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Transfected Stable Cell Lines

Human BRAF (L597Q) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0278C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human BRAF (L597Q) BAF3 Cell Line facilitates research on BRAF mutations involved in MAPK pathway activation and targeted cancer therapies.

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  • Human BRAF (L597Q) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human BRAF (L597Q) BAF3 Cell Line

Description

Human BRAF (L597Q) BAF3 Cell Line is a genetically engineered model derived from murine pro-B Ba/F3 parental cells based on customers’ requirement. BRAF (L597Q) BAF3 overexpression cell line is generated by stable integration of exogenous human BRAF containing the L597Q mutation using lentiviral transduction. Overexpression clone is validated at gene level by qRT-PCR.
Target
BRAF encodes a serine/threonine-protein kinase that activates MEK and ERK in the MAPK signaling pathway. The L597Q mutation is a kinase-activating variant found in cancers such as melanoma and colorectal cancer. It contributes to aberrant cell growth and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0278C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The BRAF (L597Q) BAF3 Cell Line is a robust platform for dissecting mutation-specific BRAF signaling, drug response profiling, and evaluation of RAF and MEK inhibitors in cancers with non-V600 BRAF alterations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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