+1 862-686-2696
Featured Products
Primary Cells
Immortalized Cell Lines
Stem Cells
Tumor Cell Lines
Transfected Stable Cell Lines
Exosomes
MicroRNA Agomir/Antagomir
Cell Culture Media, Kits & Reagents
Explore Products
Cell
Cell
MicroRNA
MicroRNA
Test and Analysis
Test and Analysis
Transfected Stable Cell Lines

Human BRCA1 (185delAG/+) MCF10A Cell Line

  • For research use only

Cat No.

ABC-KH1545
Product Type

Knockin Stable Cell Line
Species

Human
Host Cell

MCF10A
Source Organ

Breast
Disease

Fibrocystic Disease
Storage

Liquid Nitrogen

Human BRCA1 (185delAG/+) MCF10A Cell Line models hereditary breast cancer for investigating BRCA1 mutation effects on DNA repair and tumor suppressor loss.

Product Image
  • Human BRCA1 (185delAG/+) MCF10A Cell Line
Get a Quote
Home | Transfected Stable Cell Lines | Knockin Stable Cell Lines | Human BRCA1 (185delAG/+) MCF10A Cell Line

Description

Human BRCA1 (185delAG/+) MCF10A Cell line is Heterozygous knockin of 2-bp deletion in BRCA1 resulting in a premature termination codon at position 39.

Species

Human
Cat.No

ABC-KH1545
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Breast
Disease

Fibrocystic Disease
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Knockin Stable Cell Line
Host Cell

MCF10A
Stock

Custom

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • Why is “Fibrocystic Disease” listed under the “Disease” category? Can this cell line be used to study breast cancer initiation?

    The designation “Fibrocystic Disease” reflects the origin of the parental MCF10A cell line rather than a limitation of its research applications. MCF10A is a spontaneously immortalized, non-tumorigenic human mammary epithelial cell line derived from benign breast tissue with fibrocystic changes, which is why it was classified as such in its original description. The cell line retains many characteristics of normal mammary epithelial cells and does not form tumors in vivo.

    The introduction of the pathogenic BRCA1 185delAG heterozygous mutation into this near-normal cellular background is intended to model the early cellular state of breast epithelial cells in BRCA1 mutation carriers. This system enables investigation of early cancer-related processes, including increased genomic instability and susceptibility to malignant transformation under additional stresses such as secondary genetic alterations or oxidative damage.

    In this context, “fibrocystic disease” denotes the tissue origin, while “BRCA1 (185delAG/+)” defines the key oncogenic genetic alteration. Together, these characteristics make this cell line a biologically relevant model for studying the initiation and early development of breast cancer.

  • Online Inquiry
  • Product Reviews

Inquiring Human BRCA1 (185delAG/+) MCF10A Cell Line

We know how valuable your research is to you, but are you wondering what you can expect to pay for quick accurate results every time? Fill out a request in the form below and we’ll get back to you within 24 hours with a quote.
High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

Tags

Let's Advance Life Science Research Together

Contact Us
AcceGen Scroll Top Button