Human Bronchial Epithelial Cells with RA

Description

Human Bronchial Epithelial Cells (HBECs) are primary epithelial cells derived from human bronchial tissue. These cells can maintain their differentiation potential and physiological functions when cultured in the presence of retinoic acid. Morphologically, they exhibit a polygonal or cobblestone-like shape, adhere to the culture surface, and form tight junctions. These cells express the epithelial adhesion molecule E-cadherin, cystic fibrosis transmembrane conductance regulator (CFTR), and ciliary motility proteins. These molecules play crucial roles in maintaining the cell barrier function, ion transport, and ciliary movement. Functionally, HBECs clear respiratory foreign particles through mucus secretion and ciliary beating, and participate in immune defense and drug metabolism. These cells provide a system to study human bronchial epithelial cell culture with RA and the retinoic acid impact on airway cells, helping to understand differentiation, barrier formation, and ciliary function. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.