For research use only
| Cat No. | ABC-TC4379 |
| Product Type | Diseased Human Peripheral Blood Mononuclear Cells |
| Cell Type | Mononuclear Cell |
| Species | Human |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Normal |
| Storage | Liquid Nitrogen |
Human Celiac PBMCs show gliadin-reactive CD4+ T cell activation, cytokine release, and impaired Treg function, driving mucosal damage in celiac disease.
Human Celiac Disease Peripheral Blood Mononuclear Cells (PBMCs) are isolated from patients with active celiac disease, an autoimmune disorder triggered by gluten ingestion, they consist of lymphocytes (T cells, B cells, NK cells) and monocytes that drive the characteristic gluten-induced immune response. These cells exhibit disease-specific activation, particularly HLA-DQ2/DQ8-restricted CD4⁺ T cells that recognize deamidated gliadin peptides and initiate mucosal damage through proinflammatory cytokine release (IFN-γ, IL-21). The PBMC compartment in celiac disease demonstrates concurrent defects in regulatory T cells (Tregs) suppression and activation of cytotoxic CD8⁺ T cells, perpetuating the autoimmune response against intestinal tissue. Additionally, B cells within this population contribute to pathogenesis through the production of anti-tTG and anti-gliadin antibodies. These PBMCs serve as a valuable model for studying celiac disease mechanisms, including antigen-specific T cell responses, immune tolerance breakdown, and the development of therapeutic strategies targeting gluten-induced inflammation. As a disease-specific subset of Human PBMCs, these cells provide direct insight into systemic and antigen-driven immune dysregulation associated with celiac disease.
| Product Code | Human Celiac PBMC, Celiac PBMCs, hPBMC-Celiac, Human Celiac Disease Peripheral Blood Mononuclear Cells |
| Species | Human |
| Cat.No | ABC-TC4379 |
| Product Category | Primary Cells |
| Size/Quantity | 1 vial |
| Cell Type | Mononuclear Cell |
| Growth Mode | Adherent |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 ℃, 5% CO2 |
| Source Organ | Peripheral Blood |
| Disease | Normal |
| Storage | Liquid Nitrogen |
| Product Type | Diseased Human Peripheral Blood Mononuclear Cells |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Human Celiac PBMCs can be used to analyze T cell activation, proliferation and cytokine secretion (such as IFN-γ, IL-17) induced by gliadin, revealing the Th1/Th17 immune response characteristics of celiac disease. In addition, the molecular basis of antigen-specific immune response can be elucidated by detecting the clonal expansion of HLA-DQ2/DQ8-restricted T cell receptors (TCRs).
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