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Primary Cells

Human Cerebellar Granule Cells

  • For research use only

Cat No.

ABC-TC3561
Product Type

Nervous Cells
Cell Type

Granule Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Storage

Liquid Nitrogen

Advance neuroscience with Human Cerebellar Granule Cells to investigate cerebellar function, synaptic integration, and human neuronal population dynamics.

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  • Human Cerebellar Granule Cells
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Home | Primary Cells | Human Primary Cells | Nervous System Primary Cells | Human Cerebellar Granule Cells

Description

Human cerebellar granule cells (GCs) originate from neural precursors in the rhombic lip and migrate to form the densely packed granule layer, representing one of the most abundant neuronal populations in the human brain. These small, glutamatergic neurons serve as the cerebellum’s primary excitatory units, receiving sensorimotor information via mossy fibers and projecting parallel fibers to Purkinje cells, forming the fundamental circuit for motor coordination, precision timing, and posture control. Recent research demonstrates their critical role in motor learning through NMDA receptor-dependent synaptic plasticity at mossy fiber synapses, while growing evidence implicates GCs in cognitive functions like working memory through cerebellar-cortical loops. Their unique architecture and plasticity enable both fine motor control and adaptive learning capabilities. The granule cell of cerebellum plays a central role in motor learning and coordination, with its synaptic plasticity at mossy fiber synapses being crucial for adaptive responses to sensory input.

Product Code

Human Cerebellar Granule Neurons, Cerebellar Granule Cells Human, CGCs Human, Human Cerebellum Granule Neurons, Granule Neurons Cerebellum
Species

Human
Cat.No

ABC-TC3561
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Granule Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Brain
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Nervous Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and efficiency
-Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human cerebellar granule cells (GCs) serve as an essential model system for studying cerebellar function, motor learning, and neurological disorders. Their unique properties make them particularly valuable for investigating synaptic plasticity mechanisms at mossy fiber-GC synapses, which underlie motor coordination and adaptation. Researchers utilize GCs to explore the cellular basis of ataxias, autism spectrum disorders, and other conditions involving cerebellar dysfunction. These neurons are also crucial for drug screening targeting NMDA receptor-dependent plasticity and for developing therapies for motor coordination deficits. Additionally, GC cultures enable studies of neuronal migration and network formation during development. Their high abundance and well-characterized circuitry further facilitate computational modeling of cerebellar information processing, bridging cellular physiology with systems-level brain function.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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