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Human Cerebellar Granule Cells

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The development of the cerebellum involves a set of coordinated cell movements and two separate proliferation zones: the ventricular zone and the external granule cell layer (EGL), a rhombic-lip-derived progenitor pool. The EGL appears to be segregated during early cerebellum formation and produces only granule cells. Cerebellar granule cells (CGC) are the most abundant neurons […]
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Product Code

HCGC

Species

Human

Cat.No

ABC-TC3561

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Granule Cell

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Brain

Disease

Normal

Biosafety Level

1

Storage

Liquid Nitrogen

Product Type

Nervous Cells

Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and efficiency
-Quality-tested for accurate results

Description

Human Cerebellar Granule Cells (GCs) originate from neural precursor cells in the rhombic lip and are localized in the cerebellar granule layer after migration. Following migration, they become one of the most abundant neuron types in the central nervous system. Morphologically, GCs are small in size and densely arranged. As the main excitatory neurons in the cerebellar cortex, GCs are responsible for integrating sensory motor information from the spinal cord and brainstem, and participate in motor coordination, posture control and cognitive function through the parallel fiber-Purkinje cell pathway. This circuitry enables GCs to play crucial roles in motor coordination, fine movement control, and posture maintenance. Emerging evidence also suggests their involvement in specific cognitive functions. Recent studies have revealed that GCs exhibit synaptic plasticity at their mossy fiber synapses, which may contribute to motor learning and adaptation.

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Citation

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Application

  • Human Cerebellar Granule Cells have been studied extensively and often used as a model system for neuronal development, neuron survival/apoptosis and toxicity. They can also be used to build computational model of adult neuron network and development.

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