Human Corneal Epithelial Cells

Description

Human Corneal Epithelial Cells (HCECs) are primary cells isolated from the outermost layer of the cornea, exhibiting a characteristic polygonal morphology and forming tight junctions critical for maintaining the corneal barrier. These cells express key markers such as cytokeratin 3 and cytokeratin 12 (CK3/CK12), E-cadherin, and zonula occludens-1 (ZO-1), confirming their epithelial identity and function. HCECs play a vital role in corneal wound healing, tear film maintenance, and defense against pathogens. They are widely used to study dry eye disease, corneal dystrophies, and infections (e.g., herpes simplex keratitis). Each human corneal epithelial cell contributes to the integrity and regenerative capacity of the epithelium of cornea, making them indispensable for studies on ocular surface health and disease. The cells are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, syphilis, mycoplasma, fungi, yeast, and bacteria.

Application

• Human Corneal Epithelial Cells can be used to study corneal epithelial barrier function, wound healing mechanisms, and innate immune responses, such as studying the interaction between pathogens and the cornea through in vitro models. These cells can also be used to evaluate the permeability, toxicity, and repair effects of ocular drugs (such as antibiotics and anti-inflammatory drugs).