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Transfected Stable Cell Lines

Human ERBB2 (D769Y) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0353C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human ERBB2 (D769Y) BAF3 Cell Line, ERBB2, BAF3, Overexpression Stable Cell Lines, Transfected Stable Cell Lines

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  • Human ERBB2 (D769Y) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (D769Y) BAF3 Cell Line

Description

Human ERBB2 (D769Y) BAF3 Overexpression Cell Line is a genetically engineered model developed from murine BAF3 pro-B cells based on customers’ requirement. This cell line stably expresses the human ERBB2 (HER2) gene with the D769Y mutation introduced through lentiviral transduction. Gene expression is validated by qRT-PCR and the cells are maintained under low passage (<P20). Target ERBB2 (HER2) encodes a receptor tyrosine kinase overexpressed or mutated in breast, gastric, and lung cancers. The D769Y mutation is located in the kinase domain and enhances constitutive signaling, promoting cell proliferation and therapeutic resistance. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0353C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell model expresses the oncogenic D769Y mutant of ERBB2 (HER2), a variant associated with constitutive kinase activation in breast and gastric cancers. It enables functional studies of HER2 signaling, drug screening for HER2-targeted therapies, and analysis of downstream pathways like PI3K-AKT and MAPK. The cell line is widely used to evaluate therapeutic sensitivity and resistance mechanisms involving ERBB2 mutations.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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