Immortalized Human Cortical Vascular Cells

Description

Immortalized Human Cortical Vascular Cells (iHCoVCs) are derived from human cerebral cortex vasculature and genetically modified to enable long-term proliferation while retaining key endothelial and perivascular cell characteristics. These cells exhibit typical endothelial cobblestone morphology or pericyte-like spindle morphology depending on culture conditions. The cells retain functional properties including tube formation, barrier integrity, and responses to vasoactive stimuli. Compared with primary cortical vascular cells, immortalized iHCoVCs provide enhanced stability, reproducibility, and extended lifespan, making them a reliable in vitro model for neurovascular research, blood-brain barrier studies, and cerebrovascular disease modeling.