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Human ERBB2 (T798I_Q799E) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (T798I_Q799E) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0045C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (T798I_Q799E) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. ERBB2 (T798I_Q799E) BAF3 mutant cell line is generated by stable integration of exogenous human ERBB2 gene containing dual mutations (T798I and Q799E) into Ba/F3 host cells using our optimized lentiviral transduction system.
Target
ERBB2 (HER2) is a transmembrane receptor tyrosine kinase driving oncogenic signaling through PI3K/AKT and MAPK pathways. The T798I mutation is a known gatekeeper alteration associated with resistance to tyrosine kinase inhibitors, while Q799E further enhances constitutive kinase activity. The combination of these mutations allows in-depth analysis of drug resistance mechanisms in HER2-positive cancers. AcceGen offers stable models for functional and pharmacological studies of complex mutations. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The ERBB2 (T798I_Q799E) BAF3 Cell Line is an effective model for dissecting resistance to HER2-targeted therapies and evaluating second-generation inhibitors. It enables preclinical testing of novel compounds and biomarker validation in drug-resistant tumor settings.

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