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Transfected Stable Cell Lines

Human ERBB2 (V956R) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ERBB2 (V956R) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0286C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ERBB2 (V956R) BAF3 Cell Line is a genetically engineered model derived from murine Ba/F3 cells with stable integration of human ERBB2 gene carrying the V956R activating mutation. The cell line was generated using lentiviral transduction and expanded under low passage conditions (<P20). Expression is confirmed by qRT-PCR. Target ERBB2 (HER2) is a member of the ERBB receptor tyrosine kinase family involved in cell growth and differentiation. The V956R mutation occurs within the kinase domain, enhancing dimerization and downstream signaling. It is implicated in drug resistance in HER2-positive cancers. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is ideal for evaluating ERBB2 mutation-driven signaling, HER2-targeted therapy response, and resistance mechanisms in hematologic and solid tumor settings.

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