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Primary Cells

Human Esophageal Fibroblasts

  • For research use only

Cat No.

ABC-TC3613
Product Type

Esophageal Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Esophagus
Disease

Normal
Storage

Liquid Nitrogen

The Human Esophageal Fibroblasts cells from AcceGen Research Laboratories are isolated from human esophageal tissue.

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  • Human Esophageal Fibroblasts
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Description

Human Esophageal Fibroblasts (HEF) are adherent, spindle-shaped mesenchymal cells isolated from healthy human esophageal lamina propria. These fibroblasts synthesize a compliant extracellular matrix rich in type I and III collagen, contributing to connective tissue structure and wound healing in the esophagus. HEF play a key role in angiogenesis, particularly within esophageal squamous cell carcinoma models, by responding to TGF-β and secreting VEGF to stimulate endothelial network formation. They are simple to culture, supporting transfection, microinjection, and long-term studies. HEF express mesenchymal markers such as vimentin (VIM) and CD90, supporting fibroblast identity. HEF are certified for BSL-1 laboratory use, ensuring safety and reproducibility in research. Each lot undergoes rigorous screening and isolation procedures and is tested to ensure it is free from contamination by HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

Human Esophageal Fibroblasts, Esophagus Fibroblasts Human, HEFs, Esophageal Stromal Fibroblasts, Human Esophageal Connective Tissue Cells
Species

Human
Cat.No

ABC-TC3613
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Esophagus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Esophageal Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • HEF serve as robust in vitro models for studying extracellular matrix dynamics, scarring, and esophageal wound-healing processes, thanks to their collagen I/III secretion and mesenchymal properties. They are used in cancer research to investigate tumor-stromal interactions, especially the TGF-β/VEGF-mediated angiogenic support of esophageal squamous cell carcinoma. HEF are also suitable for gene modulation techniques, tissue engineering, and drug screening applications targeting fibrosis, ECM remodeling, or tumor-stromal signaling pathways.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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