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Transfected Stable Cell Lines

Human ETV6_CRAF (Y360H) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_CRAF (Y360H) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0325C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human ETV6_CRAF (Y360H) BAF3 Overexpression Cell Line is a genetically modified Ba/F3 model stably expressing the human ETV6_CRAF fusion gene with a Y360H point mutation. Lentiviral vectors are used for integration, and clonal lines are maintained at low passage numbers (<P20) and validated via qRT-PCR. Target The ETV6_CRAF fusion results in constitutive activation of the MAPK signaling pathway, with the Y360H mutation further enhancing kinase activity. This oncogenic alteration has been implicated in hematologic malignancies such as leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line is a valuable platform for elucidating ETV6_CRAF-mediated oncogenesis and for screening RAF pathway inhibitors targeting drug-resistant leukemia phenotypes.

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