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Transfected Stable Cell Lines

Human ETV6_CRAF (Y360H) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0325C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human ETV6_CRAF (Y360H) BAF3 Cell Line supports analysis of CRAF fusion-induced MAPK signaling activation and therapeutic response in leukemia models.

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  • Human ETV6_CRAF (Y360H) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human ETV6_CRAF (Y360H) BAF3 Cell Line

Description

Human ETV6_CRAF (Y360H) BAF3 Overexpression Cell Line is a genetically modified Ba/F3 model stably expressing the human ETV6_CRAF fusion gene with a Y360H point mutation. Lentiviral vectors are used for integration, and clonal lines are maintained at low passage numbers (<P20) and validated via qRT-PCR. Target The ETV6_CRAF fusion results in constitutive activation of the MAPK signaling pathway, with the Y360H mutation further enhancing kinase activity. This oncogenic alteration has been implicated in hematologic malignancies such as leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

Species

Human
Cat.No

ABC-X0325C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line is a valuable platform for elucidating ETV6_CRAF-mediated oncogenesis and for screening RAF pathway inhibitors targeting drug-resistant leukemia phenotypes.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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