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Human FGFR2 (C491S) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2 (C491S) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0037C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FGFR2 (C491S) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FGFR2 (C491S) BAF3 mutant cell line is generated by stable integration of exogenous human FGFR2 gene harboring the C491S mutation into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
FGFR2 is a transmembrane receptor tyrosine kinase that regulates cell proliferation, migration, and differentiation through FGF signaling. The C491S mutation disrupts a conserved cysteine residue in the extracellular domain, promoting ligand-independent dimerization and constitutive activation. This mutation is associated with tumorigenesis in endometrial and gastric cancers. AcceGen provides customized cell models featuring oncogenic mutations for pathway and drug discovery research. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The FGFR2 (C491S) BAF3 Cell Line is an ideal model to explore FGFR2-mediated oncogenic signaling, evaluate the efficacy of FGFR inhibitors, and study downstream resistance mechanisms. It supports high-throughput drug screening and precision therapy development for FGFR-driven malignancies.

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