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Transfected Stable Cell Lines

Human FGFR2_BICC1 (K714R) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR2_BICC1 (K714R) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0378C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human FGFR2_BICC1 (K714R) NIH/3T3 Cell Line is a genetically engineered model derived from selected murine embryonic fibroblast NIH/3T3 parental cell line based on customers’ requirement. FGFR2_BICC1 (K714R) NIH/3T3 overexpression cell line is generated by stable integration of exogenous human FGFR2-BICC1 fusion gene with the K714R point mutation into NIH/3T3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
FGFR2-BICC1 is an oncogenic gene fusion frequently observed in intrahepatic cholangiocarcinoma. The K714R mutation enhances FGFR kinase activity and oncogenicity. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • The FGFR2_BICC1 (K714R) NIH/3T3 Overexpression Cell Line provides a robust model to investigate FGFR fusion–driven tumorigenesis and to assess FGFR-targeted therapies in preclinical settings.

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