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Transfected Stable Cell Lines

Human FGFR3 (S249C_V555M) NIH/3T3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR3 (S249C_V555M) NIH/3T3 Cell Line
Species

Human
Cat.No

ABC-X0345C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Embryo
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

NIH/3T3

Description

Human FGFR3 (S249C_V555M) NIH/3T3 Overexpression Cell Line is a genetically engineered model derived from selected murine NIH/3T3 fibroblast parental cells based on customers’ requirement. FGFR3 (S249C_V555M) NIH/3T3 overexpression cell line is generated by stable integration of exogenous human FGFR3 double mutant (S249C and V555M) into NIH/3T3 host cells using our optimized transduction of lentiviral vectors. The expression cassette contains the full-length FGFR3 open reading frame carrying both activating mutations. The edited cells are maintained at low passage numbers (

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line is designed to support studies of FGFR3-driven oncogenic transformation, particularly the S249C and V555M double mutation frequently observed in bladder cancer and skeletal dysplasias. It enables in vitro screening of FGFR inhibitors, elucidation of downstream signaling events, and investigation of tumorigenic pathways involving MAPK and PI3K-AKT cascades. It is suitable for drug sensitivity profiling and mechanistic studies in fibroblast-based systems that mimic cancer-associated genetic alterations.

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