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Transfected Stable Cell Lines

Human FGFR3 (TACC3_Y373C) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0006C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocyte
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

The FGFR3 (TACC3_Y373C) BAF3 cell line provides a powerful tool for investigating the mechanisms of tumors driven by FGFR3 fusion mutations.

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  • Human FGFR3 (TACC3_Y373C) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FGFR3 (TACC3_Y373C) BAF3 Cell Line

Description

Human FGFR3 (TACC3_Y373C) BAF3 Cell Line is a genetically engineered model derived from selected murine Ba/F3 parental cell line based on customers’ requirement. FGFR3 (TACC3_Y373C) BAF3 mutant cell line is generated by stable integration of exogenous human FGFR3 gene harboring the TACC3_Y373C composite mutation/fusion into Ba/F3 host cells using our optimized transduction of lentiviral vectors.
Target
The FGFR3-TACC3 fusion involves the fibroblast growth factor receptor 3 (FGFR3) and transforming acidic coiled-coil containing protein 3 (TACC3), often coupled with point mutations such as Y373C that enhance oncogenicity. The fusion promotes constitutive FGFR3 kinase activity, disrupted mitotic spindle regulation, and activation of MAPK/ERK and PI3K/AKT pathways. This composite alteration has been observed in glioblastoma, bladder cancer, and lung cancer, and represents a potential therapeutic target. AcceGen offers generation of stable overexpression or fusion gene cell lines targeting any gene or variant of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0006C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocyte
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO₂
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The FGFR3 (TACC3_Y373C) BAF3 Cell Line serves as a powerful tool to investigate FGFR3 fusion- and mutation-driven oncogenic mechanisms and therapeutic interventions. This model enables studies of kinase activation, chromosomal instability, and drug response in hematopoietic systems. It is utilized for high-throughput screening of FGFR inhibitors and evaluation of synthetic lethality and combination therapies.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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