Human FGFR3_TACC3 (R669G) BAF3 Cell Line

Description

Human FGFR3_TACC3 (R669G) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. This cell line stably expresses the human FGFR3_TACC3 fusion gene containing the R669G mutation, introduced via lentiviral vector transduction. The edited cells are validated by qRT-PCR and maintained at low passage numbers (<P20). Target FGFR3-TACC3 is a fusion oncogene found in glioblastoma and bladder cancer, driving constitutive dimerization and aberrant activation of FGFR signaling. The R669G mutation enhances fusion-driven oncogenesis and confers resistance to some FGFR inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.