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Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

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Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
Product Code

HFLS
Species

Human
Cat.No

ABC-TC3621
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast-Like
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Synoviocytes
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Description

Human Fibroblast-Like Synoviocytes (HFLS) are primary cells derived from adult rheumatoid arthritis (RA) synovial tissue, identified as type B fibroblast-like synoviocytes, which are non-immune, spindle-shaped, and adherent. They are cryopreserved at the early passage. Unlike type A macrophage-like synoviocytes, HFLS synthesize extracellular matrix (ECM) and maintain joint structure under normal conditions. In RA, HFLS display pathogenic features like hyperproliferation, apoptosis resistance, and invasive behavior, secreting high levels of IL-6, IL-8, and MMPs to promote synovial hyperplasia and cartilage destruction. Cytogenetic analysis shows normal karyotype with no chromosomal abnormalities. They are widely used to study RA pathogenesis and anti-inflammatory drug screening. Characterization includes high vimentin and CD90 (Thy-1) expression.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (HFLS-RA) serve as a useful tool for understanding the etiology and pathogenesis of RA. They can be used to establish cellular models to study key cytokine production that contributes to RA, explore the molecular signaling pathways implicated in the development of joint inflammation, or to evaluate anti-inflammatory compounds and identify potential drug targets.

Frequently Asked Questions

  • What are Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis?

    Human Fibroblast-Like Synoviocytes are cells found in the synovial membrane of joints affected by Rheumatoid Arthritis. They play a key role in the pathogenesis of Rheumatoid Arthritis by contributing to inflammation, joint destruction, and the production of cytokines and matrix metalloproteinases.

  • What research areas are Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients used in?

    Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients are utilized in various research areas, including elucidating the molecular mechanisms underlying Rheumatoid Arthritis pathogenesis, identifying potential therapeutic targets, and screening anti-inflammatory or disease-modifying drugs.

  • Advantages of using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients

    Using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients provides a clinically relevant model system for studying the pathophysiology of Rheumatoid Arthritis. These cells retain disease-specific characteristics and can be used to investigate patient-specific responses to treatments, facilitating the development of personalized therapies for Rheumatoid Arthritis.

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