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Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult

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Human Fibroblast-Like Synoviocytes (HFLS) are isolated from synovial tissues obtained from patients with Rheumatoid Arthritis (RA) / Osteoarthritis (OA). They are cryopreserved at second passage and can be cultured and propagated at least 5 population doubling.
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Home | Primary Cells | Human Primary Cells | Motion System Primary Cells | Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis, Adult
Product Code

HFLS
Species

Human
Cat.No

ABC-TC3621
Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast-Like
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

synovium
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Synoviocytes
Key Features

– Backed by AcceGen advanced technology

– Cryopreserved for highest viability and plating efficiency

– Quality-guaranteed for accurate results

– Timely technical support for best experimental outcomes

Description

Human Fibroblast-Like Synoviocytes (HFLS), also known as synovial fibroblasts, are the predominant cell types consisting of synovial intima. Two major cell populations of synoviocytes, macrophage-like (type A) synoviocytes and fibroblast-like (type B) synoviocytes, have been identified. Abnormal fibroblast-like synoviocytes (FLS) activity is closely associated with the occurrence and progression of rheumatoid arthritis (RA), a chronic disorder marked by inflammation in the synovium. Rheumatoid arthritis FLS exhibit aggressive phenotypes and produce cytokines and proteases that perpetuate inflammation and eventually contribute to cartilage destruction. Research and therapeutic strategies targeting FLS could provide novel insight into RA diagnosis and treatment.

Why choose HFLS-RA from AcceGen?

HFLS-RA is isolated from adult joint synovial tissue with RA using AcceGen’s advanced technology. Cells at second passage are cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. HFLS-RA is characterized by fibroblast-like morphology and the expression of fibronectin using immunofluorescence. HFLS-RA is guaranteed for further expansion of at least 5 doublings following protocols provided by AcceGen.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • For research use only

  • Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis (HFLS-RA) serves as a useful tool for understanding the etiology and pathogenesis of RA. They can be used to establish cellular models to study key cytokine production that contributes to RA, to explore the molecular signaling pathways implicated in the development of joint inflammation, or to evaluate anti-inflammatory molecules and identify potential drug targets.

Frequently Asked Questions

  • What are Human Fibroblast-Like Synoviocyte Rheumatoid Arthritis?

    Human Fibroblast-Like Synoviocytes are cells found in the synovial membrane of joints affected by Rheumatoid Arthritis. They play a key role in the pathogenesis of Rheumatoid Arthritis by contributing to inflammation, joint destruction, and the production of cytokines and matrix metalloproteinases.

  • What research areas are Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients used in?

    Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients are utilized in various research areas, including elucidating the molecular mechanisms underlying Rheumatoid Arthritis pathogenesis, identifying potential therapeutic targets, and screening anti-inflammatory or disease-modifying drugs.

  • Advantages of using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients

    Using Human Fibroblast-Like Synoviocyte from Rheumatoid Arthritis patients provides a clinically relevant model system for studying the pathophysiology of Rheumatoid Arthritis. These cells retain disease-specific characteristics and can be used to investigate patient-specific responses to treatments, facilitating the development of personalized therapies for Rheumatoid Arthritis.

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