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Transfected Stable Cell Lines

Human FLT3 (F691L) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human FLT3 (F691L) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0322C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human FLT3 (F691L) BAF3 Overexpression Cell Line is engineered by introducing a human FLT3 mutant (F691L) gene into Ba/F3 cells using lentiviral transduction. The cell line is validated by qRT-PCR and maintained at low passage numbers (<P20). Target FLT3 is a receptor tyrosine kinase involved in hematopoietic stem cell proliferation. The F691L gatekeeper mutation confers resistance to multiple FLT3 inhibitors, making it a key target in relapsed acute myeloid leukemia (AML). AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers' research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This model is used to evaluate FLT3 inhibitor resistance mechanisms and to develop next-generation FLT3-targeted therapies, particularly in drug-resistant AML contexts.

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