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Species | Human |
Cat.No | ABC-TC4364 |
Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
Product Category | Primary Cells |
Size/Quantity | 1 vial |
Cell Type | Mononuclear Cell |
Shipping Info | Dry Ice |
Growth Conditions | 37 ℃, 5% CO2 |
Source Organ | Peripheral Blood |
Disease | Idiopathic Pulmonary Fibrosis |
Storage | Liquid Nitrogen |
Product Type | Diseased Human Peripheral Blood Mononuclear Cells |
Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells are immune cells isolated from the peripheral blood of Idiopathic Pulmonary Fibrosis (IPF) patients, primarily comprising lymphocytes (T cells, B cells, NK cells) and monocytes. These cells play key roles in immune regulation, inflammation, and fibrosis progression in IPF. Monocytes differentiate into profibrotic macrophages, secreting TGF-β and PDGF to activate fibroblasts, while aberrant T-cell responses exacerbate collagen deposition. IPF-PBMCs are linked to chronic inflammation, aberrant wound healing, and progressive lung scarring, with altered cytokine profiles (elevated IL-4, IL-13, IL-17A) contributing to disease pathogenesis.
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Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells can be used to study the immune pathogenesis of IPF. These cells can also be used to evaluate the immunomodulatory effects of existing anti-fibrotic drugs (such as nintedanib and pirfenidone), and to screen new therapeutic drugs targeting specific inflammatory pathways.