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Primary Cells

Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells

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Idiopathic pulmonary fibrosis is a chronic, progressive lung disease that results in scarring (fibrosis) of the lungs. Clinical data may include: Medication (current and historical), Disease severity, Lung function test results (FEV1, FEVC, PEF).
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Species

Human

Cat.No

ABC-TC4364

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial

Cell Type

Mononuclear Cell

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

Peripheral Blood

Disease

Idiopathic Pulmonary Fibrosis

Storage

Liquid Nitrogen

Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells are immune cells isolated from the peripheral blood of Idiopathic Pulmonary Fibrosis (IPF) patients, primarily comprising lymphocytes (T cells, B cells, NK cells) and monocytes. These cells play key roles in immune regulation, inflammation, and fibrosis progression in IPF. Monocytes differentiate into profibrotic macrophages, secreting TGF-β and PDGF to activate fibroblasts, while aberrant T-cell responses exacerbate collagen deposition. IPF-PBMCs are linked to chronic inflammation, aberrant wound healing, and progressive lung scarring, with altered cytokine profiles (elevated IL-4, IL-13, IL-17A) contributing to disease pathogenesis.

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Citation

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Application

  • Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells can be used to study the immune pathogenesis of IPF. These cells can also be used to evaluate the immunomodulatory effects of existing anti-fibrotic drugs (such as nintedanib and pirfenidone), and to screen new therapeutic drugs targeting specific inflammatory pathways.

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