Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells

Description

Human Idiopathic Pulmonary Fibrosis (IPF) Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of IPF patients, offering a critical tool for studying systemic immune responses in this progressive fibrotic lung disease. These PBMCs primarily comprise lymphocytes (T cells, B cells, NK cells) and monocytes. These cells play key roles in immune regulation, inflammation, and fibrosis progression in IPF. IPF PBMCs exhibit dysregulated immune profiles, including increased activation of pro-fibrotic macrophages (CD163⁺), Th2/Th17-polarized T cells, and elevated cytokine production (IL-17A, TGF-β, CCL18). These cells mirror the chronic inflammation and aberrant immune activation observed in IPF pathogenesis, providing insights into how circulating immune cells contribute to lung fibrosis. These PBMCs serve as a valuable resource for advancing IPF immunotherapy, integrating genomics PBMC IPF analyses, enabling detailed PBMC characterization lung disease, exploring PBMC metabolism IPF, and informing emerging IPF research trends.