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Human IL7Ra CRLF2 BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human IL7Ra CRLF2 BAF3 Cell Line
Species

Human
Cat.No

ABC-X0028C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

The IL7Ra CRLF2 BAF3 Cell Line is generated through stable lentiviral expression of the human IL7Rα-CRLF2 heterodimeric receptor fusion in BAF3 cells. This artificial pairing activates JAK-STAT signaling independent of cytokine stimulation. Clones are verified by qRT-PCR and maintained under selection.
Target
IL7Rα-CRLF2 overexpression is implicated in high-risk B-ALL and activates JAK2-dependent proliferative pathways. This receptor fusion serves as a model for studying cytokine receptor dysregulation in leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • This cell line is suitable for evaluating JAK-STAT pathway inhibitors, identifying novel therapeutic targets, and modeling cytokine-receptor driven leukemia.

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