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Transfected Stable Cell Lines

Human IL7Ra CRLF2 BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0028C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

This model expresses IL7Ra-CRLF2 fusion protein, offering a platform for studying lymphoid malignancies and testing JAK/STAT pathway inhibitors.

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  • Human IL7Ra CRLF2 BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human IL7Ra CRLF2 BAF3 Cell Line

Description

The IL7Ra CRLF2 BAF3 Cell Line is generated through stable lentiviral expression of the human IL7Rα-CRLF2 heterodimeric receptor fusion in BAF3 cells. This artificial pairing activates JAK-STAT signaling independent of cytokine stimulation. Clones are verified by qRT-PCR and maintained under selection.
Target
IL7Rα-CRLF2 overexpression is implicated in high-risk B-ALL and activates JAK2-dependent proliferative pathways. This receptor fusion serves as a model for studying cytokine receptor dysregulation in leukemia. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0028C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • This cell line is suitable for evaluating JAK-STAT pathway inhibitors, identifying novel therapeutic targets, and modeling cytokine-receptor driven leukemia.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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