Human Inflammatory Bowel Disease Peripheral Blood Mononuclear Cells

Description

Human Inflammatory Bowel Disease Peripheral Blood Mononuclear Cells (PBMCs) are isolated from the peripheral blood of patients with inflammatory bowel disease (IBD), primarily consisting of lymphocytes (T cells, B cells, NK cells) and monocytes. PBMCs play critical roles in immune regulation, in which T cells mediate adaptive immune responses, B cells produce antibodies, and monocytes differentiate into macrophages or dendritic cells to participate in antigen presentation and pro-inflammatory cytokine production. In IBD (including Crohn’s disease and ulcerative colitis), PBMCs exhibit an abnormally activated state characterized by enhanced Th1/Th17 cell polarization and impaired regulatory T cell (Tregs) function. This imbalance leads to elevated secretion of proinflammatory cytokines (TNF-α, IL-6) that drive chronic intestinal inflammation. These disease-derived peripheral blood mononuclear cells provide a clinically relevant platform for investigating systemic immune dysregulation and evaluating immunomodulatory therapies in IBD.