Human KIF5B_RET (I788N) BAF3 Cell Line

Description

Human KIF5B_RET (I788N) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The cell line stably expresses the human KIF5B-RET fusion gene carrying an I788N mutation, integrated via lentiviral vector transduction. Gene expression is validated by qRT-PCR and cells are maintained at low passage numbers (<P20). Target The KIF5B-RET fusion protein is an oncogenic driver identified in non-small cell lung cancer (NSCLC). The I788N mutation enhances RET kinase activity and may impact therapeutic responses to RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.