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Human KIF5B_RET (L865V) BAF3 Cell Line

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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human KIF5B_RET (L865V) BAF3 Cell Line
Species

Human
Cat.No

ABC-X0351C
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3

Description

Human KIF5B_RET (L865V) BAF3 Overexpression Cell Line is a genetically engineered model derived from murine BAF3 pro-B cells based on customers’ requirement. The cell line is constructed via stable integration of human KIF5B-RET fusion carrying a L865V mutation using optimized lentiviral transduction. The overexpressing clone is verified by qRT-PCR and maintained at low passage numbers (<P20). Target KIF5B-RET fusion proteins drive oncogenic signaling in multiple cancers. The L865V mutation lies within the RET kinase domain, and is associated with altered kinase activity or resistance to selective RET inhibitors. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

AcceGen Frozen Cells & Cell Lines 1 vial
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Application

  • For research use only

  • Designed for modeling the L865V point mutation in the KIF5B-RET fusion protein, this cell line facilitates analysis of mutation-driven signaling changes, oncogenic activity, and drug resistance. It provides a robust system for evaluating RET inhibitor efficacy, mapping phosphorylation dynamics, and testing mutation-specific responses to kinase-targeted compounds in controlled hematopoietic cell settings.

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