Human Large Intestine Microvascular Endothelial Cells

Description

Human Large Intestine Microvascular Endothelial Cells are primary endothelial cells isolated from normal human colon tissue. HLIMECs display typical cobblestone morphology and exhibit endothelial-specific markers such as CD31 and von Willebrand Factor (vWF). They contribute to studies of vascular barrier integrity, inflammation, and leukocyte transmigration in gastrointestinal tissues, underpin colonic microcirculation and endothelial cells function in the large intestine. These cells serve as reliable in vitro models for researching angiogenesis in colonic microvascular endothelium, inflammatory bowel disease models, and mediating vascular response to injury in large intestine. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.