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Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

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    1

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Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells are density separated by Ficoll-Paque from Mantle Cell Lymphoma peripheral blood. Mantle Cell Lymphoma PBMCs are available in untreated and relapsed/refractory stages.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)
Species

Human
Cat.No

ABC-TC3889
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Mantle Cell Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of patients with newly diagnosed mantle cell lymphoma (MCL) who have not received any treatment. Often characterized by t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression.They are malignant transformed cells of B-cell non-Hodgkin’s lymphoma.High expression of CD20, CD5, cyclin D1 (CCND1), SOX11. Morphologically, these cells usually appear as lymphocytes with medium size, irregular nuclei and concentrated chromatin, and some of them can be seen as “blastoid” variants, showing invasive growth characteristics.Tumorigenic, malignant cells capable of invasive growth and dissemination. Their functional abnormalities are manifested as enhanced anti-apoptosis ability, dysregulated proliferation and immune escape.

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Citation

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Application

  • Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) can be used as an in vitro cell model to study the pathogenesis of mantle cell lymphoma (MCL), such as studying the proliferation disorder, apoptosis resistance and signaling pathway abnormalities (such as BCR, NF-κB and PI3K pathways) of MCL. These cells can also be used to evaluate the efficacy and resistance mechanism of targeted drugs such as BTK inhibitors (such as ibrutinib) and BCL-2 inhibitors (such as venetoclax).

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