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Primary Cells

Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

  • For research use only

Cat No.

ABC-TC3889
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Cell Type

Mononuclear Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Mantle Cell Lymphoma
Storage

Liquid Nitrogen

Human Mantle Cell Lymphoma PBMCs (Newly Diagnosed/Untreated) support lymphoma immunology, biomarkers, and therapy evaluation in patient samples. in lab.

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  • Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated)

Description

Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) are derived from the peripheral blood of patients with newly diagnosed mantle cell lymphoma (MCL) who have not received any treatment. These cells are often characterized by t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. They contain malignant transformed cells of B-cell non-Hodgkin’s lymphoma, and show high expression of CD20, CD5, cyclin D1 (CCND1), SOX11. Morphologically, these cells usually appear as lymphocytes with medium sized, irregular nuclei and condensed chromatin, and some of them can be seen as “blastoid” variants, showing invasive growth characteristics. Their functional abnormalities are manifested as enhanced anti-apoptosis ability, dysregulated proliferation and immune escape. In translational and clinical studies, these samples are widely used to analyze gene expression profiles, investigate disease progression and immune responses, and evaluate emerging therapeutic strategies in mantle cell lymphoma.

Species

Human
Cat.No

ABC-TC3889
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Mantle Cell Lymphoma
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Mantle Cell Lymphoma Peripheral Blood Mononuclear Cells (Newly Diagnosed/Untreated) can be used as an in vitro cell model to study the pathogenesis of mantle cell lymphoma (MCL), such as dysregulated proliferation, apoptosis resistance and signaling pathway abnormalities (including BCR, NF-κB and PI3K pathways) of MCL. These cells can also be used to evaluate the efficacy and resistance mechanism of targeted drugs such as BTK inhibitors (such as ibrutinib) and BCL-2 inhibitors (such as venetoclax).

Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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