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Human Mobilized Peripheral Blood Mononuclear Cells, CD34 Depleted

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CD34 is a well-known marker for primitive and bone marrow-derived progenitor cells, especially for hematopoietic and endothelial progenitors. AcceGen offers CD34+ progenitor cells in a phenotypically undifferentiated state. The progenitor cells are derived from the peripheral blood of healthy donors that have undergone G-CSF mobilization. Progenitor cells contain two main cellular subpopulations, hematopoietic and endothelial […]
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Mobilized Peripheral Blood Mononuclear Cells, CD34 Depleted
Species

Human
Cat.No

ABC-TC3707
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Normal Human Peripheral Blood Mononuclear Cells

Description

Human Mobilized Peripheral Blood Mononuclear Cells (PBMCs), CD34 Depleted, is a mononuclear cell population isolated from peripheral blood mobilized by cytokines (such as G-CSF), and the cell components after CD34+ hematopoietic stem cells are specifically removed by immunomagnetic beads or flow cytometry. Cells grow predominantly in suspension culture in vitro, with no adherent growth.The morphology shows typical mononuclear cell characteristics, including round or oval cell morphology, and kidney-shaped or lobed nuclei. Express typical surface markers such as CD3 (T cells), CD19 (B cells), CD56 (NK cells), CD14 (monocytes); CD34+ cells specifically depleted.These cells are mainly composed of lymphocytes (T cells, B cells, NK cells) and monocytes, and play a key role in innate and adaptive immune responses, including antigen presentation, cytotoxic killing and cytokine secretion.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as "AcceGen Biotech Cat.# XXX-0000". In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

  • Human Mobilized Peripheral Blood Mononuclear Cells (PBMCs), CD34 Depleted can be used to study non-hematopoietic stem cell-mediated immune regulation mechanisms, such as graft-versus-host disease (GVHD), autoimmune diseases (such as rheumatoid arthritis) and tumor immunotherapy (such as CAR-T cell therapy). These cells can also be used to explore the pathological mechanisms related to abnormal activation or functional defects of immune cells, and provide an experimental basis for the treatment strategy of immune-related diseases.

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