Human Peripheral Blood Monocyte Derived Macrophages

Description

Human Peripheral Blood (PB) Monocyte-Derived Macrophages (MDMs) are generated from negatively selected monocytes isolated from human peripheral blood. After primary culture, the cells are cryopreserved. Functionally, these macrophages exhibit potent phagocytic activity, enabling them to ingest pathogens, debris, and foreign particles. They also act as antigen-presenting cells (APCs), initiating adaptive immune responses by presenting antigens to T cells. Their central role in immunity makes them valuable for studying host defense, inflammation, and immunotherapy. In vitro, Human Peripheral Blood Monocyte Derived Macrophages have limited proliferative capacity. Repeated freeze-thaw cycles should be avoided during culture. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.