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Transfected Stable Cell Lines

Human MPL (W515R) BAF3 Cell Line

  • For research use only

Cat No.

ABC-X0358C
Product Type

Overexpression Stable Cell Lines
Cell Type

Lymphocytes
Species

Human
Host Cell

BAF3
Source Organ

Lymphatic
Disease

Normal
Storage

Liquid Nitrogen

Human MPL (W515R) BAF3 Cell Line, MPL, BAF3, Overexpression Stable Cell Lines, Transfected Stable Cell Lines

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  • Human MPL (W515R) BAF3 Cell Line
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Home | Transfected Stable Cell Lines | Overexpression Stable Cell Lines | Human MPL (W515R) BAF3 Cell Line

Description

Human MPL (W515R) BAF3 Cell Line is a genetically engineered model derived from selected murine pro-B Ba/F3 parental cell line based on customers’ requirement. MPL (W515R) BAF3 overexpression cell line is generated by stable integration of exogenous human MPL (W515R) mutant gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
The MPL gene encodes the thrombopoietin receptor, a member of the cytokine receptor family involved in hematopoietic stem cell maintenance and megakaryopoiesis. The W515R mutation leads to constitutive activation of downstream JAK-STAT signaling, and is recurrently found in myeloproliferative neoplasms (MPNs), contributing to cytokine-independent growth and transformation. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.

Species

Human
Cat.No

ABC-X0358C
Product Category

Transfected Stable Cell Lines
Size/Quantity

1 vial
Cell Type

Lymphocytes
Growth Mode

Suspension
Shipping Info

Dry Ice
Growth Conditions

37 °C, 5% CO2
Source Organ

Lymphatic
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Overexpression Stable Cell Lines
Host Cell

BAF3
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • The MPL (W515R) BAF3 Overexpression Cell Line serves as a robust model to study the role of MPL mutations in hematologic malignancies, particularly their impact on cytokine-independent proliferation, JAK-STAT pathway activation, and drug resistance. It is ideal for high-throughput screening of JAK inhibitors and targeted therapies for MPNs.

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
Tailed to your research

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