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Primary Cells

Human Nucleus Pulposus Cells

  • For research use only

Cat No.

ABC-TC3728
Product Type

Cartilage Cells
Cell Type

Nucleus Pulposus Cell
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Nucleus Pulposus
Disease

Normal
Storage

Liquid Nitrogen

Human Nucleus Pulposus Cells maintain disc matrix, express HIF-1α, secrete cytokines, respond to mechanical stress, and are key in disc degeneration.

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Description

Human Nucleus Pulposus Cells (HNPCs) are primary chondrocyte-like cells isolated from human intervertebral discs and cryopreserved at early passages to preserve their native phenotype. They exhibit limited proliferative capacity, rounded morphology, and express key chondrogenic markers such as SOX9, ACAN, COL2A1, and FOXF1. HNPCs are positive for mesenchymal surface markers (CD73⁺, CD90⁺, CD44⁺) and negative for hematopoietic markers (CD34⁻, CD45⁻). These cells also express HIF-1α and secrete cytokines including IL-1, IL-6, IL-10, and GM-CSF, contributing to immune modulation and matrix maintenance. Nucleus pulposus cell degeneration is a key event in intervertebral disc degeneration (IVDD) and associated chronic back pain. Owing to their role in matrix synthesis and responsiveness to mechanical and inflammatory cues, HNPCs are widely used in disc degeneration modeling, senescence research, and the evaluation of regenerative therapies such as stem cell-based interventions and biomaterial scaffolds.

Product Code

Human Nucleus Pulposus Cells, Intervertebral Disc Nucleus Pulposus Cells, NP Cells Human, Human Disc NP Cells, Nucleus Pulposus Chondrocyte-like Cells
Species

Human
Cat.No

ABC-TC3728
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Nucleus Pulposus Cell
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Nucleus Pulposus
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Cartilage Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Nucleus Pulposus Cells (HNPCs) serve as an in vitro model for investigating cellular and molecular mechanisms underlying intervertebral disc degeneration (IDD). Researchers utilize these cells to study ECM metabolism under mechanical stress or inflammatory cytokine exposure, including IL-1β and TNF-α. HNPCs are employed in tissue engineering to evaluate biocompatibility and regenerative potential of biomaterials such as collagen scaffolds or hydrogel systems. Their cytokine secretion profiles (IL-6, IL-10, and GM-CSF) support analysis of immune modulation during degenerative processes. Moreover, HNPCs are employed in drug screening to test therapeutic agents targeting MMP inhibition, enhancing aggrecan synthesis or promoting disc repair.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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