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Primary Cells

Human Oral Epithelial Cells

  • For research use only

Cat No.

ABC-TC4365
Product Type

Oral Cells
Cell Type

Epithelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Oral
Disease

Normal
Storage

Liquid Nitrogen

Human Oral Epithelial Cells simulate oral mucosal barriers and are used in inflammation, microbial adhesion, and epithelial regeneration modeling.

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  • Human Oral Epithelial Cells
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Description

Human oral epithelial cells (HOECs) are isolated from human oral mucosal tissue. These cells form the first line of defense for the oral mucosa, shielding it from microbial invasion and toxic agents. In addition, they participate in immune responses by secreting inflammatory mediators (such as cytokines IL-1β, IL-6 and IL-8) after infection, injury or immune stimulation. Their ability to produce antimicrobial peptides (e.g., defensins and cathelicidins) further enhances the defense mechanisms within the oral cavity. HOECs also express epithelial-specific markers such as cytokeratins 13 and 14, E-cadherin, and involucrin, which are crucial for epithelial differentiation and barrier integrity. Abnormalities in HOEC function are closely associated with various oral diseases, including oral squamous cell carcinoma (where they undergo malignant transformation), recurrent aphthous ulcers (characterized by epithelial breakdown), and periodontal disease (involving epithelial barrier dysfunction). Oral epithelial cells are a specialized subset of human epithelial cells that form the oral epithelium, where the mucosal epithelial layer plays a key role in maintaining tissue homeostasis and immune balance.

Species

Human
Cat.No

ABC-TC4365
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Oral
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Oral Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Oral Epithelial Cells can be used as an in vitro model to study the pathogenesis of oral mucosal diseases, such as analyzing the effects of pathogenic factors on cell proliferation and apoptosis. They can also provide a toxicity testing and efficacy evaluation platform for drug development and verify the biocompatibility of candidate drugs with oral tissues.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).
Shaikh SB, Tung WC, Pang C, Lucas J, Li D, Rahman I. Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Oral Gingival Epithelial Cells and Bronchial Epithelial Cells. Toxics. 2022;10(11):660. Published 2022 Oct 31. doi:10.3390/toxics10110660

Frequently Asked Questions

  • What are Human Oral Epithelial Cells, and how are they isolated?

    Human Oral Epithelial Cells are the cells that line the surface of the oral cavity. They are typically isolated from human oral mucosa tissue through enzymatic digestion followed by selective culturing.

  • What research applications are Human Oral Epithelial Cells used for?

    These cells are commonly used in studies of oral diseases, wound healing, cancer research, drug delivery systems, and the effects of various oral care products.

  • What are the ideal storage conditions for Human Oral Epithelial Cells?

    These cells should be stored in liquid nitrogen vapor phase at temperatures below -150°C to preserve their viability for future use.

  • What are the differences between Human Oral Epithelial Cells and other types of epithelial cells?

    Human Oral Epithelial Cells are specifically derived from the lining of the oral cavity, which gives them unique properties compared to other epithelial cells, such as those from the skin or respiratory tract. They are particularly well-suited for studies involving oral health, mucosal immunity, cancer, and tissue regeneration in the oral environment. Their gene expression profiles and responses to stimuli can differ significantly from other epithelial cell types, making them ideal for oral-specific research applications.

  • What is the recommended number of passages for culturing these cells after receipt

    Human oral epithelial cells are recommended for approximately 3 passages to maintain consistent morphology and functional characteristics.

  • What type of epithelium lines the oropharynx?

    The oral cavity and oropharynx are primarily lined by stratified squamous epithelium. This epithelium can be keratinized or non-keratinized depending on the region, providing protection against mechanical stress and microbial invasion.

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