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Primary Cells

Human Oral Epithelial Cells

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Cells are only guaranteed with purchase of AcceGen Media, Extra Cellular Matrix, Trypsin EDTA, 1X PBS, and freezing media for the appropriate cell culture, for 30 days from the date of shipment.
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Oral Epithelial Cells
Species

Human
Cat.No

ABC-TC4365
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Epithelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Oral
Disease

Normal
Storage

Liquid Nitrogen
Product Type

Oral Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human oral epithelial cells are isolated from human oral mucosal tissue. These cells form the first line of defense for the oral mucosa, shielding it from microbial invasion and toxic agents.. In addition, they participate in immune responses by secreting inflammatory mediators (such as cytokines IL-1β, IL-6, IL-8) after infection, injury or immune stimulation [1-2]. Their ability to produce antimicrobial peptides (e.g., defensins and cathelicidins) further enhances the oral cavity’s defense mechanisms. HOECs also express epithelial-specific markers such as cytokeratins 13 and 14, E-cadherin, and involucrin, which are crucial for epithelial differentiation and barrier integrity. Abnormalities in HOEC function are closely associated with various oral diseases, including oral squamous cell carcinoma (where they undergo malignant transformation), recurrent aphthous ulcers (characterized by epithelial breakdown), and periodontal disease (involving epithelial barrier dysfunction).

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Shaikh, Sadiya Bi et al. “Flavor Classification/Categorization and Differential Toxicity of Oral Nicotine Pouches (ONPs) in Oral Gingival Epithelial Cells and Bronchial Epithelial Cells.” Toxics vol. 10,11 660. 31 Oct. 2022, doi:10.3390/toxics10110660

Application

  • Human Oral Epithelial Cells can be used as an in vitro cell model to study the pathogenesis of oral mucosal diseases, such as analyzing the effects of pathogenic factors on cell proliferation and apoptosis. They can also provide a toxicity testing and efficacy evaluation platform for drug development and verify the biocompatibility of candidate drugs with oral tissues.

Frequently Asked Questions

  • What are Human Oral Epithelial Cells, and how are they isolated?

    Human Oral Epithelial Cells are the cells that line the surface of the oral cavity. They are typically isolated from human oral mucosa tissue through enzymatic digestion followed by selective culturing.

  • What research applications are Human Oral Epithelial Cells used for?

    These cells are commonly used in studies of oral diseases, wound healing, cancer research, drug delivery systems, and the effects of various oral care products.

  • What are the ideal storage conditions for Human Oral Epithelial Cells?

    These cells should be stored in liquid nitrogen vapor phase at temperatures below -150°C to preserve their viability for future use.

  • What are the differences between Human Oral Epithelial Cells and other types of epithelial cells?

    Human Oral Epithelial Cells are specifically derived from the lining of the oral cavity, which gives them unique properties compared to other epithelial cells, such as those from the skin or respiratory tract. They are particularly well-suited for studies involving oral health, mucosal immunity, cancer, and tissue regeneration in the oral environment. Their gene expression profiles and responses to stimuli can differ significantly from other epithelial cell types, making them ideal for oral-specific research applications.

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