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Human Ovarian Cancer Peripheral Blood Mononuclear Cells

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Included Diagnoses: Serous and other carcinomas of the ovary, Endometrial adenocarcinoma (including all subtypes) and Squamous Cell Carcinoma (including all subtypes),Neuroendocrine tumors of the ovary, Brenner Tumors.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Ovarian Cancer Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4363
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Ovarian Cancer
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Ovarian Cancer Peripheral Blood Mononuclear Cells are immune cells isolated from the peripheral blood of ovarian cancer patients, primarily comprising lymphocytes (T cells, B cells, NK cells) and monocytes. These cells play a critical role in antitumor immune responses, including antigen presentation (monocytes/macrophages), cytotoxic activity (NK and CD8+ T cells), and antibody production (B cells). In ovarian cancer, PBMCs are often functionally impaired due to tumor-mediated immunosuppression, characterized by increased regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and exhausted T cell phenotypes, which contribute to immune evasion and disease progression].

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Ovarian Cancer Peripheral Blood Mononuclear Cells can be used to analyze the immune escape mechanism of ovarian cancer, such as detecting the increase in the proportion of regulatory T cells (Tregs) and the expansion of myeloid-derived suppressor cells (MDSCs). These cells can also be used to screen biomarkers that predict the efficacy of immune checkpoint inhibitors and evaluate the feasibility of adoptive cell therapies such as CAR-T.

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