Human Pancreatic Alpha Cells

Description

Human Pancreatic Alpha Cells are primary cells isolated from human pancreatic islets, responsible for the secretion of glucagon, a hormone that raises blood glucose levels during hypoglycemia. These cells are characterized by the expression of glucagon, a key marker for alpha cells. In vitro, they exhibit responsiveness to glucose and other stimuli, making them valuable for studying glucose homeostasis and endocrine pancreas function. Human Pancreatic Alpha Cells also serve as a model for investigating alpha cell dysfunction in diabetes and exploring potential therapeutic strategies for diabetes management.

Application

• For research use only.

• Human Pancreatic Alpha Cells are used to study glucagon secretion mechanisms, glucose sensing, and interactions between islet cells. They are employed in diabetes research, particularly in understanding alpha cell dysfunction in type 1 and type 2 diabetes. Additionally, these cells provide a model for drug screening and regenerative medicine studies, with an emphasis on developing therapies for beta cell restoration through alpha cell transdifferentiation.