Human Pancreatic Cancer Peripheral Blood Mononuclear Cells

Description

Human Pancreatic Cancer Peripheral Blood Mononuclear Cells (PBMCs) are primarily derived from the peripheral blood of pancreatic cancer patients using density gradient centrifugation, providing a critical immune cell population for studying the immunosuppressive pancreatic tumor microenvironment. These PBMCs contain altered ratios of T cells (including elevated Tregs and exhausted CD8⁺ T cells), B cells, NK cells, and monocytes, exhibiting characteristic pancreatic cancer-associated immune signatures such as increased PD-1/CTLA-4 expression and TGF-β secretion. Morphologically, PBMCs are generally round or oval. In the tumor microenvironment, these cells can participate in anti-tumor or tumor-promoting processes by secreting cytokines (such as IL-6, TNF-α) and mediating immune responses, among which regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs) may facilllitate immune escape. These PBMCs support comprehensive PBMC phenotyping pancreatic cancer, evaluation of autoimmune markers in pancreatic cancer, monitoring of pancreatic cancer progression, optimized PBMC isolation pancreatic cancer, and investigation of immune modulation and immune response in pancreatic cancer.