Human Pancreatic Cancer Peripheral Blood Mononuclear Cells

Description

Human Pancreatic Cancer Peripheral Blood Mononuclear Cells are primarily derived from the peripheral blood of pancreatic cancer patients. They are a mixed cell population separated from the blood by density gradient centrifugation, including lymphocytes (T cells, B cells, NK cells) and monocytes. Morphologically, PBMCs are generally round or oval. In the tumor microenvironment, these cells can participate in anti-tumor or tumor-promoting processes by secreting cytokines (such as IL-6, TNF-α) and mediating immune responses, among which regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs) may facilllitate immune escape.

Application

• Human Pancreatic Cancer Peripheral Blood Mononuclear Cells can be used to study the tumor immune microenvironment, such as evaluating the activity and immunosuppressive mechanisms of T cells, NK cells, B cells, and myeloid cells in pancreatic cancer or studying the effects of pro-inflammatory (such as IL-6, TNF-α) or anti-inflammatory factors (such as IL-10, TGF-β) secreted by PBMCs on tumor progression.