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Human Periodontal Ligament Fibroblasts

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The periodontal ligament is a connective tissue located between the cementum of teeth and the alveolar bone of the mandibula. It plays an integral role in the maintenance and regeneration of periodontal tissue. The cells responsible for maintaining this tissue are thought to be fibroblasts, which can be either multipotent or composed of heterogenous cell […]
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Home | Primary Cells | Human Primary Cells | Digestive System Primary Cells | Human Periodontal Ligament Fibroblasts
Product Code

HPDLF
Species

Human
Cat.No

ABC-TC3750
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Periodontal Ligament
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Oral Cells
Key Features

-Backed by AcceGen advanced technology
-Cryopreserved for highest viability and plating efficiency
-Quality-tested for accurate results

Description

Human Periodontal Ligament Fibroblasts (PLFs) are derived from human periodontal ligament tissue. They are the predominant cell type in periodontal ligament and play an important role in the development, function, and regeneration of periodontal connective tissues. PLFs are considered multipotent cells and involved in the synthesis and phagocytosis of collagen and matrix components, secretion of cytokines, as well as osteoclastogenesis. While morphologically resembling gingival fibroblasts, PLFs stand apart in their unique biological responses, matrix protein expression, and elevated alkaline phosphatase activity — a signature of their bone remodeling prowess. PLFs express typical mesenchymal markers such as vimentin, STRO-1, and alkaline phosphatase (ALP).Their unique ability to differentiate into osteoblast-like cells under certain conditions highlights their critical role in maintaining periodontal homeostasis and supporting bone remodeling.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Periodontal Ligament Fibroblasts can be used to explore the pathogenesis of periodontitis, drug screening and tissue engineering research. For example, by simulating an inflammatory environment, the effects of cytokines (such as IL-6, TNF-α) on periodontal tissue destruction can be analyzed, or the effects of new biomaterials (such as hydrogels, scaffolds) on cell adhesion and proliferation can be evaluated

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