Human Peripheral Blood BDCA4+ Lymphoid/Plasmacytoid Dendritic Cells

Description

Human Peripheral Blood (PB) BDCA4+ Lymphoid/Plasmacytoid Dendritic Cells are isolated from human peripheral blood and cryopreserved after primary culture. These cells are characterized by the expression of BDCA4, also known as CD304 or neuropilin-1. Plasmacytoid dendritic cells play a crucial role in both innate and adaptive immunity, particularly through the rapid secretion of large amounts of type I interferons in response to viral infections. In addition, they produce various cytokines and chemokines that regulate immune responses and influence the balance between pro-inflammatory and anti-inflammatory pathways. In vitro, BDCA4+ cells display limited proliferative capacity. It is important to avoid repeated freeze-thaw cycles during handling to maintain their functional integrity. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.