Human Prostate Stromal Cells

Description

Human Prostate Stromal Cells are primary cells isolated from the stromal compartment of healthy adult human prostate tissue. These cells are cryopreserved following primary culture. Prostate stromal cells play a critical role in maintaining prostate architecture, secreting growth factors, and regulating epithelial cell behavior through paracrine signaling. These bipolar, adherent cells exhibit typical mesenchymal morphology and express markers such as vimentin, α-smooth muscle actin (α-SMA), and CD90. Upon stimulation with TGF-β, they secrete cytokines such as IL-6 and BMP-6, which activate androgen receptor (AR) signaling in co-culture with prostate cancer cells. Additionally, they express progesterone receptors and influence cancer cell motility. Estrogen signaling through the ERK pathway also modulates their proliferative behavior. In vitro, these cells display limited proliferative capacity and is recommended to avoid repeated freeze-thaw cycles. Human Prostate Stromal Cells are ideal for studies on prostate disease mechanisms and hormone signaling pathways.