Human Pulmonary Art Endothelial Cells-Diabetic Type II

Description

Human Pulmonary Artery Endothelial Cells (HPAEC)-Diabetic Type II are primary endothelial cells isolated from pulmonary arteries of donors with clinically diagnosed Type II diabetes. These cells exhibit characteristic cobblestone morphology, adhere to culture vessels, and proliferate under optimized endothelial growth conditions. Cryopreserved upon supply, they are maintained at early passage to preserve the native diabetic phenotype. Functionally, they exhibit impaired nitric oxide–mediated vasodilation and elevated NADPH oxidase (NOX) activity, reflecting known endothelial dysfunction under hyperglycemia. These cells express endothelial markers including PECAM-1 and VE‑cadherin, and demonstrate uptake of acetylated LDL and binding to Ulex europaeus lectin—confirming their authentic vascular endothelial identity. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.