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Human Pulmonary Pericytes

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Product Name

Human Pulmonary Pericytes

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Cat.No

ABC-H0044X

Species

Human

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Pulmonary pericytes are specialized mesenchymal cells embedded within the alveolar capillary basement membrane. They envelop capillaries and have processes forming focal contact with endothelial cells. Pericytes in the lung help maintain structural integrity and contribute to vascular repair after lung injury. Lung pericytes can sense danger signals and amplify inflammatory responses by elaborating cytokines. Disruption in pericyte-endothelial cell interaction (PDGF-PDGFRβ signaling axis) can lead to abnormal vasculogenesis in early embryonic development.

Why choose Human Pulmonary Pericytes from AcceGen?

Human pulmonary pericytes are derived from healthy human lungs with fully consented donors using AcceGen’s advanced technology. Cells are immediately cryopreserved to ensure the best viability. Each vial contains more than 5×10^5 cells in 1ml volume. Human pulmonary pericytes are quality tested with the expression of platelet-derived growth factor-ß (PDGFRß) and α-smooth muscle actin by immunofluorescence.

Disease

Normal

Source Organ

Lung

Quality Control

All cell lots test negative for HIV-1, HBV, HCV, mycoplasma, yeast, fungi, and other pathogens.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

For research use only
Growing evidence suggests a central role for pericytes as myofibroblast precursors, contributing to the development of lung disorders such as fibrosis and asthma. Human pulmonary pericytes provide an easily accessible model for studying the biology and pathophysiology of primary pericytes. Studying the interactions between pericytes and endothelial cells, pericytes and other pulmonary cells may provide novel insight into pulmonary circulation and the pathogenesis of lung disorders.

Key Features

– Backed by AcceGen advanced technology
– Cryopreserved for highest viability and plating efficiency
– Quality-guaranteed for accurate results
– Timely technical support for best experimental outcomes

Growth Conditions

37 ℃, 5% CO2

Cell Type

Pericyte

Growth Mode

Adherent

Product Type

Pulmonary Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Frequently Asked Questions

  • What are pulmonary pericytes?

    Pulmonary pericytes are specialized contractile cells found wrapped around the endothelial cells of capillaries and venules in the lungs. They play a crucial role in maintaining blood vessel stability, regulating blood flow, and supporting the endothelial cells.

  • What is the primary function of pulmonary pericytes?

    The primary function of pulmonary pericytes is to provide structural support to blood vessels, regulate blood-brain barrier integrity, influence blood flow, and participate in the repair and regeneration of the vasculature in the lungs.

  • Is dysfunction of pulmonary pericytes associated with the development of pulmonary diseases?

    Yes, dysfunction of pulmonary pericytes is closely related to pulmonary diseases such as pulmonary hypertension, fibrosis, and chronic obstructive pulmonary disease (COPD). Their malfunction can lead to abnormal vascular remodeling, inflammation, and tissue scarring, exacerbating the progression of these conditions.

  • How do pulmonary pericytes interact with endothelial cells?

    Pulmonary pericytes interact with endothelial cells through direct physical contact and paracrine signaling. These interactions are essential for blood vessel stability, regulation of permeability, and angiogenesis.

  • What signaling pathways are involved in pulmonary pericyte function?

    Key signaling pathways involved in pulmonary pericyte function include the PDGF (platelet-derived growth factor) pathway, TGF-β (transforming growth factor-beta) pathway, and Notch signaling. These pathways regulate pericyte proliferation, migration, and differentiation.

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