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Primary Cells

Human Splenic Endothelial Cells

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The spleen performs essential functions in the turnover of erythrocytes. It removes erythrocytes, metabolizes hemoglobin, and recycles iron. The spleen also mounts a primary immune response to antigens in the blood and synthesizes antibodies in its white pulp. Human splenic endothelial cells (HSEC), resembling endothelial cells from other parts of the body, constitute the natural […]
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Splenic Endothelial Cells
Product Code

HSEC
Species

Human
Cat.No

ABC-TC3817
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.
Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Spleen Cells
Key Features

-Backed by AcceGen advanced technology

-Cryopreserved for highest viability and plating efficiency

-Quality-tested for accurate results

-Expert teams to provide timely support and assist best experimental outcomes

Description

Human Splenic Endothelial Cells are derived from human spleen tissue. These cells are endothelial-like and grow in an adherent manner. These are primary cells typically used at low passage to preserve phenotypic characteristics.The cells have a variety of important functions, including forming the structural basis of microvessels, participating in regulating vascular permeability and integrity, and playing a key role in immune response and inflammatory response by releasing cytokines and other bioactive substances. They express endothelial markers such as CD31 (PECAM-1), von Willebrand factor (vWF), and VE-cadherin, typically identified by immunocytochemistry or flow cytometry.Karyotype is generally normal in early passages and not routinely assessed.They are important for maintaining the normal function of the spleen and preventing infection, while providing a supportive microenvironment for the development of dendritic cells.

AcceGen Frozen Cells & Cell Lines 1 vial
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Citation

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Application

  • Human Splenic Endothelial Cells can be used to explore the immune regulation mechanisms of the spleen, such as how they participate in antigen presentation, lymphocyte migration, and inflammatory responses. These cells can also be used to evaluate drug metabolism, the targeted delivery of nanoparticles, or the mechanism of action of immunomodulatory drugs.

Frequently Asked Questions

  • What role do Human Splenic Endothelial Cells play in immune system function?

    These cells are essential for regulating immune responses by filtering blood and interacting with lymphocytes.

  • Are Human Splenic Endothelial Cells involved in the clearance of aged or damaged red blood cells?

    Yes, these cells play a critical role in the removal of old or damaged red blood cells from circulation.

  • Can Human Splenic Endothelial Cells be used to study vascular diseases specific to the spleen?

    Yes, they are suitable for researching splenic vascular disorders and immune-related conditions.

  • How do Human Splenic Endothelial Cells contribute to the spleen's filtration of pathogens?

    These cells help trap and clear pathogens from the bloodstream, supporting the spleen’s immune functions.

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