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Primary Cells

Human Splenic Endothelial Cells

  • For research use only

Cat No.

ABC-TC3817
Product Type

Spleen Cells
Cell Type

Endothelial
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Storage

Liquid Nitrogen

Human Splenic Endothelial Cells are CD31+ VE-cadherin+ vWF+ cells supporting microvessel function, cytokine release, and splenic immune development.

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  • Human Splenic Endothelial Cells
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Splenic Endothelial Cells

Description

Human Splenic Endothelial Cells are derived from human spleen tissue. These cells display typical endothelial characteristics and grow in an adherent manner. These are primary cells typically used at low passage to preserve phenotypic characteristics. The cells have a variety of important functions, including forming the structural basis of microvessels, participating in regulating vascular permeability and integrity, and playing a key role in immune response by releasing cytokines and other bioactive substances. They express endothelial markers such as CD31 (PECAM-1), von Willebrand factor (vWF), and VE-cadherin, typically identified by immunocytochemistry or flow cytometry. Karyotype is generally normal in early passages and not routinely assessed. They are important for maintaining the normal function of the spleen and preventing infection, while providing a supportive microenvironment for the development of dendritic cells. These spleen cells, representing the major endothelial component among cells in spleen, provide a useful model for comparing endothelial cells vs epithelial cells and for studying vascular and immune functions of cells in the spleen.

Product Code

HSEC
Species

Human
Cat.No

ABC-TC3817
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Endothelial
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Spleen Cells
Key Features

-Backed by AcceGen advanced technology

-Cryopreserved for highest viability and plating efficiency

-Quality-tested for accurate results

-Expert teams to provide timely support and assist best experimental outcomes
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human Splenic Endothelial Cells can be used to explore the immune regulation mechanisms of the spleen, such as how they participate in antigen presentation, lymphocyte migration, and inflammatory responses. These cells can also be used to evaluate drug metabolism, the targeted delivery of nanoparticles, or the mechanism of action of immunomodulatory drugs.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What role do Human Splenic Endothelial Cells play in immune system function?

    These cells are essential for regulating immune responses by filtering blood and interacting with lymphocytes.

  • Are Human Splenic Endothelial Cells involved in the clearance of aged or damaged red blood cells?

    Yes, these cells play a critical role in the removal of old or damaged red blood cells from circulation.

  • Can Human Splenic Endothelial Cells be used to study vascular diseases specific to the spleen?

    Yes, they are suitable for researching splenic vascular disorders and immune-related conditions.

  • How do Human Splenic Endothelial Cells contribute to the spleen's filtration of pathogens?

    These cells help trap and clear pathogens from the bloodstream, supporting the spleen’s immune functions.

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High Viability
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To support a consistent result
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