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Primary Cells

Human Splenic Fibroblasts

  • For research use only

Cat No.

ABC-TC3818
Product Type

Spleen Cells
Cell Type

Fibroblast
Species

Human
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Storage

Liquid Nitrogen

Human Splenic Fibroblasts from white pulp regulate lymphocyte migration and antigen presentation, vital for immune function and vascular research.

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  • Human Splenic Fibroblasts
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Home | Primary Cells | Human Primary Cells | Immune System Primary Cells | Human Splenic Fibroblasts

Description

Human Splenic Fibroblasts are primary cells isolated from the spleen tissue of healthy human donors, a key secondary lymphoid organ essential for immune regulation and hematopoiesis. Derived specifically from the white pulp, they exhibit spindle-shaped, elongated morphology and adherent growth in vitro. They play a key role in maintaining the spleen’s structural integrity and extracellular matrix production. They contribute to the spleen’s immune microenvironment by interacting with immune cells and regulating inflammation and tissue repair. These fibroblasts include T-zone reticular cells (CCL21⁺), follicular dendritic cells (CXCL13⁺, CR1/2⁺), and marginal reticular cells (CXCL13⁺, MAdCAM1⁺, RANKL⁺). These cells express fibroblast markers such as vimentin, fibronectin, and alpha-smooth muscle actin (α-SMA) under activation conditions. Human splenic fibroblasts are valuable for studying fibrosis, immune cell-stromal interactions, and diseases affecting the spleen such as splenomegaly and fibrotic disorders.

Product Code

HSF
Species

Human
Cat.No

ABC-TC3818
Product Category

Primary Cells
Size/Quantity

1 vial
Cell Type

Fibroblast
Growth Mode

Adherent
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Spleen
Disease

Normal
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Spleen Cells
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human splenic fibroblasts can be used to identify receptors and markersinvolved in proliferation, tissue repair, and inflammation. They are useful for establishing in vitro disease models for high-throughput and high-content screening, allowing researchers to investigate disease mechanisms and test potential interventions. Additionally, studying the role of spleen fibroblasts in the spleen’s structure and their modulation of surrounding immune cells provides insights into immune functions and host defense mechanisms.

Citation

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $200 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Frequently Asked Questions

  • What is the primary function of Human Splenic Fibroblasts in the spleen's architecture?

    These fibroblasts provide structural support to the spleen and maintain the integrity of splenic tissue.

  • Can Human Splenic Fibroblasts be used for studying fibrosis in splenic diseases?

    Yes, they are suitable for investigating the role of fibroblasts in splenic fibrosis and related pathologies.

  • What are the typical culture conditions for Human Splenic Fibroblasts?

    They should be cultured in a fibroblast-specific medium, supplemented with essential growth factors.

  • How do Human Splenic Fibroblasts interact with immune cells in the spleen?

    These cells play a role in modulating immune responses by interacting with various immune cell types.

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