Primary Cells

Human Synoviocytes

  • For research use only

Cat No.

ABC-TC3829

Product Type

Synoviocytes

Cell Type

Synoviocyte

Species

Human

Growth Conditions

37 ℃, 5% CO2

Source Organ

synovium

Disease

Normal

Storage

Liquid Nitrogen

Human synoviocytes, the predominant cell type of healthy synovial tissue, are fibroblast-like cells.

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Description

Human Synoviocytes (hS) are isolated from the synovial membrane lining the joints, typically collected from healthy donors or patients undergoing joint surgery. These cells include primarily fibroblast-like synoviocytes (FLS), which are mesenchymal in origin and display an elongated, spindle-shaped morphology when cultured. hS adhere to culture dishes and grow in a monolayer, with a moderate proliferation rate and stable phenotype across early passages. Functionally, they play a central role in maintaining joint homeostasis through the production of extracellular matrix components such as hyaluronan and collagen, as well as inflammatory mediators like IL-6, IL-8, and prostaglandins, especially under pathological conditions. Flow cytometry and immunocytochemistry confirm the expression of mesenchymal markers including CD90 and vimentin. The cells undergo rigorous screening and isolation procedures, and are rigorously tested to ensure they are free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.
Product Code

HS

Species

Human

Cat.No

ABC-TC3829

Product Category

Primary Cells

Size/Quantity

1 vial

Cell Type

Synoviocyte

Growth Mode

Adherent

Shipping Info

Dry Ice

Growth Conditions

37 ℃, 5% CO2

Source Organ

synovium

Disease

Normal

Storage

Liquid Nitrogen

Product Type

Synoviocytes

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Application

  • Human synoviocytes (hS) serve as a physiologically relevant in vitro model for studying joint disease pathogenesis, including rheumatoid arthritis and osteoarthritis. These cells are key contributors to synovial inflammation and are widely used to investigate pro-inflammatory cytokine production, matrix metalloproteinase activation, and synovial hyperplasia. hS are also used to study molecular crosstalk between synovial tissue and cartilage, particularly in processes leading to cartilage degradation and joint remodeling. They are commonly applied in high-throughput drug screening for anti-inflammatory and disease-modifying compounds, as well as in mechanistic studies of fibroblast-like synoviocyte activation and angiogenesis associated with pannus formation.

Citation

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Inquiring Human Synoviocytes

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High Viability
To succeed in cell culture
Precision and Reliability
To support a consistent result
Customization Options
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