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Human Thyroid Microvascular Endothelial Cells

Product Name

Human Thyroid Microvascular Endothelial Cells

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Cat.No

ABC-TC106L

Species

Human

Cell Type

Endothelial

Growth Mode

Adherent

Size/Quantity

1 vial

Biosafety Level

1

Shipping Info

Dry Ice

Storage

Liquid Nitrogen

Description

Human Thyroid Microvascular Endothelial Cells, derived from thyroid tissue, represent a pure population of endothelial cells, as they tested positive for factor VIII-related antigen while being negative for thyroglobulin and calcitonin. These cells express fibroblast growth factor (FGF)-2, FGF receptor (FGFR1), and Tie-2. They possess an intriguing autocrine response to FGF-2, while also being receptive to paracrine factors like vascular endothelial growth factor (VEGF), albeit as a less potent mitogen, which stimulates FGFR1 expression. Additionally, the cells exhibit responsiveness to paracrine antiangiogenic signals from thrombospondin (TSP-1) and angiostatin, induced by thyroid follicular cell-conditioned medium, contributing to their role in angiogenesis regulation.

 

Why choose Human Thyroid Microvascular Endothelial Cells from AcceGen?

Human Thyroid Microvascular Endothelial Cells exhibit high viability and quality, having been incubated and cryopreserved under optimal conditions. They are ensured to be sterile, with thorough testing confirming their negativity for HIV-1, HBV, and HCV. The presence of endothelial markers is assessed using immunofluorescence staining or FACS, and stringent quality control measures ensure their reliability and suitability for various research applications.

Disease

Normal

Source Organ

Thyroid

Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Recommended Medium And Supplement
Citation Guide

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

Application

FOR RESEARCH USE ONLY

Human Thyroid Microvascular Endothelial Cells offer a crucial application in studying thyroid angiogenesis and its involvement in goitrogenesis. These cells serve as an invaluable tool for exploring the intricate cross-talk between endothelial and follicular cells during this process. Moreover, they are extensively used as a standard model to analyze changes in growth factors, unveiling the molecular mechanisms underlying neoangiogenesis in human thyroid tumors, including thyroid carcinoma cell lines. These applications pave the way for a deeper understanding of thyroid-related vascular biology and the development of potential therapeutic interventions.

Growth Conditions

37 ℃, 5% CO2

Product Type

Thyroid Cells

Product Image AcceGen Frozen Cells & Cell Lines 1 vial

Related Resources

When you publish your research, please cite our product as “AcceGen Biotech Cat.# XXX-0000”. In return, we’ll give you a $100 coupon. Simply click here and submit your paper’s PubMed ID (PMID).

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