For research use only
| Cat No. | ABC-X0064C |
| Product Type | Overexpression Stable Cell Lines |
| Cell Type | Lymphocytes |
| Species | Human |
| Host Cell | BAF3 |
| Source Organ | Lymphatic |
| Disease | Normal |
| Storage | Liquid Nitrogen |
TNK1-AAA BAF3 Cell Line is optimized for studying tyrosine kinase activity modulation and screening therapeutic strategies targeting TNK1 signaling.
The Human TNK1_AAA BAF3 Cell Line is a genetically engineered model derived from the murine pro-B cell line BAF3 based on customers’ requirement. This overexpression cell line is generated by stable integration of exogenous human TNK1_AAA fusion gene into BAF3 host cells using our optimized transduction of lentiviral vectors. Overexpression clone is validated at gene level by qRT-PCR.
Target
TNK1_AAA represents a constitutively active form of TNK1 (tyrosine kinase non-receptor 1) modified to include gain-of-function mutations. TNK1 is a cytoplasmic tyrosine kinase implicated in innate immunity and tumor suppression. Mutant forms may drive pro-survival signaling through NF-κB and STAT pathways. AcceGen offers generation of stable overexpression cell lines targeting any gene of your interest. Polyclonal or monoclonal is optional based on customers’ research needs.
| Species | Human |
| Cat.No | ABC-X0064C |
| Product Category | Transfected Stable Cell Lines |
| Size/Quantity | 1 vial |
| Cell Type | Lymphocytes |
| Growth Mode | Suspension |
| Shipping Info | Dry Ice |
| Growth Conditions | 37 °C, 5% CO2 |
| Source Organ | Lymphatic |
| Disease | Normal |
| Biosafety Level | 1 |
| Storage | Liquid Nitrogen |
| Product Type | Overexpression Stable Cell Lines |
| Host Cell | BAF3 |
| Quality Control | All cells test negative for mycoplasma, bacteria, yeast, and fungi. |
The Human TNK1_AAA BAF3 Cell Line enables functional studies on TNK1-mediated oncogenic transformation and signaling dynamics. It supports discovery of TNK1-targeted compounds and understanding of inflammatory and hematologic disease pathogenesis.