Human Tonsil Microvascular Endothelial Cells

Description

Human Tonsil Microvascular Endothelial Cells (HTMECs) are endothelial cells isolated from the microvasculature of human tonsils. These cells are a subtype of vascular endothelial cells, primarily lining the small blood vessels within tonsillar tissue. HTMECs exhibit a cobblestone-like appearance when confluent in vitro, with a flattened, polygonal shape and a central nucleus, typical of endothelial cells. They form confluent monolayers and demonstrate contact inhibition. These cells regulate vascular permeability, immune cell recruitment, and angiogenesis, playing a vital role in tonsillar immune responses. HTMECs are relevant for studying inflammatory conditions such as chronic tonsillitis. HTMECs are characterized by high expression of CD31. To ensure the quality of these primary cells, repeated freeze-thaw cycles are not recommended due to the fragile nature of these cells. Each lot undergoes rigorous screening and isolation procedures, and is rigorously tested to ensure it is free of contamination from HIV-1, HBV, HCV, Syphilis, Mycoplasma, Fungi, Yeast, and Bacteria.