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Human Type I Diabetes Peripheral Blood Mononuclear Cells

  • BSL

    1

  • 110
Peripheral blood mononuclear cells are isolated from Type I Diabetes peripheral blood by diluting the whole blood with PBS and using gradient separation techniques. After centrifugation,the mononuclear cell layer is collected. Mononuclear Cells can be processed further to isolate subpopulations. Fresh Diabetic Type I PBMCs is available upon request.
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Home | Primary Cells | Human Primary Cells | PBMCs | Human Type I Diabetes Peripheral Blood Mononuclear Cells
Species

Human
Cat.No

ABC-TC4263
Quality Control

All cells test negative for mycoplasma, bacteria, yeast, and fungi.

Product Category Primary Cells
Size/Quantity

1 vial
Cell Type

Mononuclear Cell
Shipping Info

Dry Ice
Growth Conditions

37 ℃, 5% CO2
Source Organ

Peripheral Blood
Disease

Type I Diabete
Biosafety Level

1
Storage

Liquid Nitrogen
Product Type

Diseased Human Peripheral Blood Mononuclear Cells

Description

Human Type I Diabetes Peripheral Blood Mononuclear Cells are isolated from the peripheral blood of patients with type I diabetes (T1D). Typical mononuclear cells with round nuclei, grow in suspension.Type 1 diabetes is an autoimmune disease characterized by the immune system’s mistaken attack on pancreatic β cells, resulting in an absolute lack of insulin secretion.Altered expression of metabolic and inflammatory markers, increased lipid peroxidation-related genes, dysregulated mitochondrial genes PBMCs from patients with T1D show metabolic abnormalities, with increased lipid accumulation, increased lipid peroxidation, and impaired mitochondrial function when exposed to fatty acids or inflammatory factors (TNF-α) .Functional abnormalities linked to autoimmune destruction of pancreatic β cells, immune dysregulation, and metabolic stress in PBMCs.

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Application

  • Human Type I Diabetes Peripheral Blood Mononuclear Cells can be used to study the immune pathogenesis of type I diabetes and reveal the key pathways by which immune cells attack pancreatic β cells. They can also be used to evaluate the effects of immunomodulatory drugs on the activity of T cells and NK cells.

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