IL-4 Reporter Cell Line

Description

Interleukin-4 (IL-4) is a cytokine crucial for the differentiation of Th0 into Th2 cells, which have anti-inflammatory properties. IL-4 is mainly secreted by Th2 cells, forming a Th2 cell loop. Other important functions of IL-4 include promoting the proliferation and differentiation of B cells, inducing the synthesis of immunoglobulin E antibodies, playing a significant role in allergic reactions. Additionally, IL-4 induces macrophage polarization into the anti-inflammatory M2 phenotype, aiding in reducing pathological inflammation. The main signaling occurs through the binding of IL-4 to IL-4Rα and γc, activating downstream signaling pathways.The IL-4 Reporter Cell Line is a gene reporting cell line that does not express human IL-13RA1 and IL-13RA2 receptors, thus specifically identifying human IL-4 without recognizing human IL-13. When human IL-4 binds to the receptors, downstream signaling pathways are activated, leading to the expression of luciferase. This cell line can be used to evaluate the in vitro effects of IL-4-related drugs.